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KMID : 0939920100420030151
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대한암학회지
2010 Volume.42 No. 3 p.151 ~ p.156
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Up-regulation of RhoGDI2 in Human Breast Cancer and Its Prognostic Implications
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Moon Hyeong-Gon
Jeong Sang-Ho
Ju Young-Tae
Jeong Chi-Young
Lee Jong-Sil
Lee Young-Joon
Hong Soon-Chan
Choi Sang-Kyeong
Ha Woo-Song
Park Soon-Tae
Jung Eun-Jung
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Abstract
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Purpose:Recent research has identified many genes and proteins that play specific roles in the process of systemic metastasis in various types of cancer. Rho GDP dissociation inhibitor 2 (RhoGDI2) has been shown to inhibit metastasis in human bladder cancer, but its role in breast cancer is controversial.
Materials and Methods :We examined the regulation and clinical significance of RhoGDI2 in Korean breast cancer patients by using proteomic approaches.
Results:By using a proteomic approach, we observed an increased expression of RhoGDI2 in human breast cancer tissues when compared to that of the normal breast tissues, and we validated its up-regulation in an independent cohort of 8 breast cancer patients. The clinical implication of a RhoGDI2 expression was investigated in 57 breast cancer patients by performing immunohistochemistry. RhoGDI2 did not show a significant association with the tumor size, lymph node metastasis, the histologic grade or the hormone receptor status. However, the patients with RhoGDI2-expressing tumors had significantly shorter disease-free survival (p=0.043; hazard ratio, 3.87) and distant metastasis-free survival (p=0.039; hazard ratio, 5.15).
Conclusion:Our results demonstrated a potential role of RhoGDI2 as a poor prognostic marker as well as a potential therapeutic target. The pro-metastatic nature of RhoGDI2 shown in our study may indicate its organ-specific role in cancer metastasis.
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KEYWORD
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Breast neoplasms, RhoGDI2 protein, Prognosis, Neoplasm metastasis, Proteomics
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